Tesamorelin Dosage: A Complete Guide
The standard tesamorelin dosage is 2 mg injected subcutaneously once daily.
The newer Egrifta WR™ formulation delivers 1.28 mg (0.16 mL) daily with the same efficacy but a smaller injection volume and easier preparation.
What Is Tesamorelin and Why Dosage Matters
Tesamorelin is a synthetic growth hormone–releasing hormone (GHRH) analog that stimulates the pituitary gland to release growth hormone (GH), increasing insulin-like growth factor 1 (IGF-1) levels.
It’s FDA-approved for treating HIV-associated lipodystrophy, but it’s also used in wellness and aesthetic medicine to reduce abdominal fat, improve metabolism, and support muscle preservation.
Getting the dosage right is essential.
Consistent and precise dosing helps achieve visible fat loss while maintaining safe hormone levels and minimizing side effects.
Standard Tesamorelin Dosage
According to the National Library of Medicine, the standard tesamorelin dosage is: 2 mg injected subcutaneously once daily, preferably at the same time each day.
Key Administration Details
- Formulation: Each vial contains 2 mg of tesamorelin as a lyophilized powder.
- Reconstitution: Mix with sterile water before injection.
- Route: Subcutaneous (under the skin), usually in the lower abdomen.
- Duration: Long-term use may be needed to maintain results, as visceral fat can return after discontinuation.
Egrifta SV® vs Egrifta WR™: What’s Changed
In 2024, the manufacturer Theratechnologies introduced a new formulation called Egrifta WR™, designed for more convenient dosing.
| Formulation | Daily Dose | Volume | Reconstitution | Advantages |
| Egrifta SV® (Original) | 2 mg | 0.5 mL | Reconstitute with sterile water | Proven efficacy |
| Egrifta WR™ (New) | 1.28 mg | 0.16 mL | Weekly reconstitution | Easier prep, smaller injection volume |
Egrifta WR™ maintains the same clinical effectiveness with fewer preparation steps, making it simpler and more user-friendly.
How Tesamorelin Works in the Body
Tesamorelin mimics natural GHRH, prompting the pituitary gland to release GH.
This increase in GH and IGF-1 levels helps:
- Stimulate lipolysis (fat metabolism)
- Support muscle tone and recovery
- Improve energy, metabolism, and body composition
Because tesamorelin’s half-life is around 1 hour, consistent daily injections are key for sustained results.
How to Inject Tesamorelin Correctly
Proper injection technique helps ensure consistent absorption and reduces irritation.
- Reconstitute the powder with the provided sterile water.
- Gently swirl, never shake, until the solution is clear.
- Draw the prescribed dose into a syringe.
- Inject into the abdomen, rotating sites daily.
- Dispose of the syringe safely.
Most people inject tesamorelin before bedtime to align with the body’s natural GH release pattern.
Monitoring and Dose Adjustments
Most users remain at the standard daily dose.
Adjustments are rarely necessary unless your provider recommends it.
Dose modification may be needed if you experience:
- Elevated IGF-1 levels
- Blood sugar changes or insulin resistance
- Fluid retention or joint pain
Routine lab testing, including IGF-1, fasting glucose, HbA1c, and lipid profiles, ensures safety and effectiveness.
Off-Label Use in Wellness and Aesthetics
Beyond its FDA-approved indication, tesamorelin is often used in medspa and regenerative medicine settings for:
- Reducing abdominal or visceral fat
- Preserving lean muscle mass
- Enhancing recovery and metabolism
In these wellness applications, the 2 mg daily dose typically remains standard, though some providers modify schedules, such as 5 days on and 2 days off, to align with patient goals.
These protocols should always be medically supervised by a provider like Nulevel Wellness Medspa.
When to Discuss a Dosage Change
You may need to review your dosage with your provider if:
- You experience persistent swelling, numbness, or tingling
- IGF-1 or glucose levels move outside your target range
- You’re not seeing expected results after several months of consistent use
Providers may adjust the timing, switch formulations, or combine tesamorelin with peptides such as CJC-1295 or Ipamorelin for synergistic effects.
Tesamorelin Side Effects and Dose Relationship
Most tesamorelin side effects are mild and related to dose or injection technique.
Common side effects include:
- Redness or discomfort at the injection site
- Mild swelling or joint stiffness
- Tingling in fingers or hands
- Water retention
Less common side effects of tesamorelin include:
- Elevated blood sugar or insulin resistance
- Hand or foot swelling
- Allergic reactions (rare)
Regular monitoring and consistent dosing reduce these risks significantly.
How Nulevel Wellness Medspa Personalizes Tesamorelin Therapy
At Nulevel Wellness Medspa, we personalize every tesamorelin treatment based on your health, metabolism, and goals.
Our experienced clinicians monitor your progress, labs, and hormone balance to ensure your dosage is safe and effective.
We combine advanced peptide protocols with a holistic approach to support body composition, recovery, and overall vitality.
Learn more about our peptide therapy or schedule your consultation today.
FAQs: Tesamorelin Dosage
What are the benefits of tesamorelin?
Tesamorelin helps reduce visceral fat, improve body composition, and support a healthier metabolism. By stimulating the natural release of growth hormone, it promotes fat breakdown, muscle preservation, and better energy balance. Many users also notice improved sleep, recovery, and cognitive clarity after consistent use.
Does tesamorelin build muscle?
Tesamorelin doesn’t directly build muscle like anabolic agents, but it helps preserve and maintain lean mass by increasing growth hormone and IGF-1 levels. This hormonal response improves protein synthesis and recovery, making it easier to gain or retain muscle while reducing body fat.
What are the benefits of tesamorelin for men?
For men, tesamorelin can support a leaner, more defined physique by targeting stubborn abdominal fat while maintaining muscle mass. It may also enhance energy levels, workout recovery, libido, and sleep quality — benefits often linked to higher natural growth hormone activity.
How long until tesamorelin kicks in?
Most people begin noticing changes within four to six weeks of consistent daily use, though significant fat reduction and body composition improvements may take three to six months. Results depend on lifestyle, diet, and adherence to the prescribed dosage.
What are the benefits of tesamorelin vs ipamorelin?
Both peptides stimulate growth hormone release, but tesamorelin works by mimicking GHRH, while ipamorelin mimics ghrelin. Tesamorelin is typically stronger for fat reduction and metabolic improvement, whereas ipamorelin is gentler and often used for recovery, sleep, and overall wellness. Some providers combine both for enhanced fat loss and hormone balance.
