Ozempic and Testosterone

If you’re using Ozempic for weight loss and starting to notice changes in your energy, mood, or sex drive, you’re not imagining things. 

Many men are now wondering if Ozempic affects testosterone and whether adding testosterone replacement therapy (TRT) might help.

At Nulevel Wellness Medspa we provide both semaglutide (the active ingredient in Ozempic) and TRT, so this is a conversation we have all the time. 

Here’s what you need to know if you’re thinking about combining the two.

What is Ozempic?

Ozempic is a brand name for semaglutide, a GLP-1 medication originally used to treat type 2 diabetes. 

Studies show that it is known for helping people lose weight by:

• Controlling blood sugar
  
• Reducing appetite
  
• Slowing digestion
  
• Helping you feel fuller longer
  

It’s helped thousands of people lose weight, but it can also cause unexpected side effects, including those that mimic low testosterone symptoms.

What Does Testosterone Do?

Testosterone plays a major role in how men feel and perform. 

It supports:

• Muscle strength
  
• Sex drive
  
• Energy
  
• Mood
  
• Mental focus
  

When testosterone levels drop, it often leads to fatigue, low libido, weight gain, poor sleep, and irritability. 

Excess body fat can lower testosterone even more, creating a cycle that’s tough to break without help.

Does Ozempic Lower Testosterone?

There’s no strong research proving that Ozempic directly reduces testosterone levels. 

But a lot of men report symptoms like low energy, low sex drive, or even erectile dysfunction while using it.

Why? 

As you lose fat quickly with Ozempic, it can shift how your body manages hormones. 

If your testosterone was already low, the symptoms might just become more obvious. 

Some men also lose muscle along with fat, which can affect how strong and energized they feel.

So while Ozempic might not lower testosterone directly, it can definitely highlight hormonal imbalances that were hiding under the surface.

Why Some Men Use Ozempic and Testosterone Together

Pairing semaglutide with TRT isn’t about “boosting results”, it’s about feeling your best while your body changes. 

Here’s why men choose both:

• Preventing muscle loss during weight loss
  
• Keeping energy levels and motivation high
  
• Maintaining a healthy sex drive
  
• Supporting mental focus and mood
  

When done safely and under medical supervision, using Ozempic and testosterone together can be a powerful combination. 

At Nulevel Wellness Medspa, we help men through every step of that journey. 

Contact us to learn more about our testosterone replacement therapy.

Can Semaglutide Improve Low T Symptoms?

Semaglutide might help with low testosterone. 

Losing body fat can help your body naturally produce more testosterone. 

In fact, we often see testosterone levels improve just from weight loss alone. 

But if your testosterone is already low, weight loss might not be enough on its own.

That’s where TRT comes in. 

It helps fill the gap so you’re not just leaner, but also stronger, more energized, and more focused. 

Are There Side Effects When Combining Ozempic and TRT?

Every treatment has potential side effects. 

With semaglutide, some people notice nausea, constipation, or appetite suppression that’s too intense. 

With testosterone, common side effects include acne, fluid retention, or mood changes, especially if dosing isn’t personalized.

That’s why it’s important to work with a clinic that tailors your treatment to your body. 

At Nulevel, we don’t guess. 

We test your hormones, review your goals, and build a plan that fits.

How Do You Know If You Need Both?

If you’re losing weight on Ozempic but still feel tired, unmotivated, or not like yourself, it’s worth checking your testosterone levels. 

You might be a good candidate for both semaglutide and TRT if you:

• Have low energy even after weight loss
  
• Struggle to maintain muscle
  
• Notice a drop in sex drive or mood
  
• Feel like something’s missing, even though you’re “doing everything right”
  

We start with lab testing and a consultation to understand what’s really going on. 

Then we guide you through treatment with regular check-ins and adjustments.

How We Help at Nulevel Wellness Medspa

We’re here to help you feel like yourself again. 

At Nulevel Wellness Medspa we offer:

• Personalized TRT programs
  
• Full hormone testing and analysis
  
• Ongoing medical support to fine-tune your treatment
  

We don’t take shortcuts. 

We take the time to understand your body and goals so your treatment actually works, for the long run.

Final Thoughts: Ozempic and Testosterone

Ozempic and testosterone can work well together, but it depends on your individual needs. 

Some men see great results with semaglutide alone. 

Others need testosterone support to stay strong, energized, and balanced as they lose weight.

At Nulevel, we help you figure out the best path forward based on real data, not guesswork. 

If you’re ready to explore what’s possible when your hormones and metabolism are working together, we’re ready to help.

Reach out today to schedule your consultation.

FAQs: Ozempic and Testosterone

Can you take testosterone with Ozempic?

Yes, you can take testosterone while using Ozempic. Many men do so to help preserve muscle, support libido, and maintain energy levels during weight loss. It’s important to be monitored by a healthcare provider to ensure both treatments are working safely and effectively together.

Does Ozempic cause low testosterone?

Ozempic itself doesn’t directly lower testosterone, but some men may notice symptoms like low libido or fatigue while on it. These effects may be due to existing low testosterone becoming more noticeable during rapid weight loss.

Can semaglutide raise testosterone levels?

Semaglutide doesn’t directly increase testosterone, but weight loss from semaglutide can lead to improved hormone balance. Losing excess body fat may help your body naturally produce more testosterone over time.

Can you build muscle on Ozempic?

Building muscle on Ozempic is possible, especially if you maintain a high-protein diet and strength train regularly. However, some men may lose muscle mass during weight loss, which is why testosterone therapy is sometimes used alongside Ozempic to support muscle preservation.

Is semaglutide the same as Ozempic?

Yes, semaglutide is the active ingredient in Ozempic. Ozempic is the brand name used for treating type 2 diabetes and is also prescribed off-label for weight loss.

What are the benefits of tirzepatide vs semaglutide?

Tirzepatide is another injectable medication that works on both GLP-1 and GIP receptors, which may lead to greater weight loss for some individuals. Semaglutide works only on the GLP-1 receptor. Both are effective, but tirzepatide may provide additional benefits in certain cases.